Eastern Florida , Eastern Georgia , South Carolina

I-95 N

I-95 N to I-26 W; I-26 W to Columbia, SC; I-77 N to Charlotte; continue on I-77 toward Yadkinville, take 421 N toward Wilkesboro, take 16 N to Jefferson or 221 to N to West Jefferson/Jefferson

Central and Western Florida , Western Georgia

I-75N

I-75 N to Atlanta; I-85 N to I-77 N to Charlotte; continue on I-77 toward Yadkinville, take 421 N toward Wilkesboro, take 16 N to Jefferson or 221 to N to West Jefferson/Jefferson

Alabama , Georgia , South Carolina

I-85 N

I-85 N to Charlotte ; continue on I-77 toward Yadkinville, take 421 N toward Wilkesboro, take 16 N to Jefferson or 221 to N to West Jefferson/Jefferson

Tennessee , Arkansas , Oklahoma

I-40 E

I-40 E to Knoxville ; I-81 N to Marion , VA. Take 16 S to Jefferson

Ohio , Kentucky , Western Pennsylvania

I-75 S

I-75 S to Knoxville ; I-81 N to Marion , VA. Take 16 S to Jefferson

Ohio , West Virginia

I-77 S

I- 77 S to Hwy. 58W toward Galax, VA. At Mouth of Wilson, VA take Hwy. 16 S to Jefferson

New York , Eastern Pennsylvania , Washington DC , Virginia

I-81 S

I-81 S to I-77 S. Take I- 77 S to Hwy. 58W toward Galax, VA. At Mouth of Wilson, VA take Hwy. 16 S Jefferson

Virginia

I-85 S

I-85 S to Durham , NC ; I-40 W to Winston-Salem ; US Hwy. 421 N to Wilkesboro. Take 16 N to Jefferson or 221 to N to West Jefferson/Jefferson

Eastern North Carolina
(Winston-Salem , Raleigh , Greenville )

I-40 W

I-40 W to Winston-Salem ; US Hwy. 421 N to Wilkesboro. Take 16 N to Jefferson or 221 to N to West Jefferson/Jefferson

Southern North Carolina
(Charlotte )

I-77 N

I-77 N (Charlotte) toward Yadkinville, take 421 N toward Wilkesboro, take 16 N to Jefferson or 221 to N to West Jefferson/Jefferson